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Therapeutic Advances in Cardiovascular Disease
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Review: Aspirin and Diabetes Mellitus: revisiting an old player

Camila Manrique

University of Missouri Columbia, Department of Internal Medicine, Endocrinology and Diabetes Department, Harry S Truman VA Hospital, Columbia, MO, 1, Hospital Drive, Columbia, MO, 65 211, USA

Guido Lastra

University of Missouri Columbia, Department of Internal Medicine, Endocrinology and Diabetes Department, Harry S Truman VA Hospital, Columbia, MO, 1, Hospital Drive, Columbia, MO, 65 211, USA

John Palmer

University of Missouri Columbia, Department of Internal Medicine, Endocrinology and Diabetes Department, Harry S Truman VA Hospital, Columbia, MO, 1, Hospital Drive, Columbia, MO, 65 211, USA

Michael Gardner

University of Missouri Columbia, Department of Internal Medicine, Endocrinology and Diabetes Department, Harry S Truman VA Hospital, Columbia, MO, 1, Hospital Drive, Columbia, MO, 65 211, USA

James R. Sowers

University of Missouri Columbia, Department of Internal Medicine, Endocrinology and Diabetes Department, Harry S Truman VA Hospital, Columbia, MO, 1, Hospital Drive, Columbia, MO, 65 211, USA, sowersj{at}health.missouri.edu

Type 2 Diabetes Mellitus confers an excess risk of cardiovascular disease. The mechanisms involved in the development of the disease are an active field of research, and prompt the development of newer and safer therapeutics with implications for cardiovascular disease. Currently there is increasing awareness of the role of platelet dysfunction, low-grade chronic inflammation and thrombogenesis in the pathophysiology of insulin resistance, T2DM, as well as type 1 diabetes mellitus and cardiovascular disease. This new evolving knowledge has allowed a better understanding of the role of aspirin, an old medication with proven beneficial effects on patients with established cardiovascular disease. The influence of salicylates on insulin resistance, glucose homeostasis, platelet function and inflammatory pathways, in particular related to the activation of the NF{kappa}B pathway, is a promising field of active research, and will help in the management of both diabetes mellitus and atherosclerotic-related cardiovascular disease.

Key Words: salicylates • aspirin • type 2 diabetes mellitus • insulin resistance • inflammation • NF{kappa}B pathway • platelet dysfunction • thrombogenesis

Therapeutic Advances in Cardiovascular Disease, Vol. 2, No. 1, 37-42 (2008)
DOI: 10.1177/1753944707088185
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