Therapeutic Advances in Cardiovascular Disease

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here for more information

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrow Add to My Marked Citations
Google Scholar
Right arrow Articles by Cheng, C.
Right arrow Articles by Falkner, B.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Therapeutic Advances in Cardiovascular Disease, Vol. 2, No. 2, 79-88 (2008)
DOI: 10.1177/1753944708089696
© 2008 SAGE Publications

Original Research: Capillary rarefaction in treated and untreated hypertensive subjects

Cynthia Cheng

Department of Family and Community Medicine, Thomas Jefferson University Hospital, Curtis Bldg, Suite 401, 1015 Walnut Street, Philadelphia, PA 19107, Cynthia.Cheng@ jefferson.edu

Constantine Daskalakis

Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University

Bonita Falkner

Department of Internal Medicine, Thomas Jefferson University

This study aimed to determine if capillary rarefaction is detectable and associated with endothelial dysfunction in persons with mild systolic blood pressure (SBP) elevation. Capillary density and endothelial function were quantified for 150 nondiabetic participants, grouped by blood pressure (BP) as normotensive, untreated high BP, and treated high BP. Structural capillary rarefaction measures were not different between the three groups. Functional capillary rarefaction measures were significantly lower in both high BP groups compared to normotensives, and correlated inversely with endothelial function. The study findings indicate that the hypertensive vascular pathologic process is already underway at modest levels of blood pressure elevation.

Key Words: Hypertension • essential • microcirculation • endothelial dysfunction • capillary density • microvascular function


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?