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Therapeutic Advances in Cardiovascular Disease
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Original Research: Capillary rarefaction in treated and untreated hypertensive subjects

Cynthia Cheng

Department of Family and Community Medicine, Thomas Jefferson University Hospital, Curtis Bldg, Suite 401, 1015 Walnut Street, Philadelphia, PA 19107, Cynthia.Cheng@ jefferson.edu

Constantine Daskalakis

Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University

Bonita Falkner

Department of Internal Medicine, Thomas Jefferson University

This study aimed to determine if capillary rarefaction is detectable and associated with endothelial dysfunction in persons with mild systolic blood pressure (SBP) elevation. Capillary density and endothelial function were quantified for 150 nondiabetic participants, grouped by blood pressure (BP) as normotensive, untreated high BP, and treated high BP. Structural capillary rarefaction measures were not different between the three groups. Functional capillary rarefaction measures were significantly lower in both high BP groups compared to normotensives, and correlated inversely with endothelial function. The study findings indicate that the hypertensive vascular pathologic process is already underway at modest levels of blood pressure elevation.

Key Words: Hypertension • essential • microcirculation • endothelial dysfunction • capillary density • microvascular function

Therapeutic Advances in Cardiovascular Disease, Vol. 2, No. 2, 79-88 (2008)
DOI: 10.1177/1753944708089696
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