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Therapeutic Advances in Cardiovascular Disease
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*Cholesterol
*Stem Cells
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Review: Hypercholesterolemia-associated endothelial progenitor cell dysfunction

Matteo Pirro

Medicina Interna, Angiologia e Malattie da Arteriosclerosi, Università degli Studi di Perugia, Ospedale S. Maria della Misericordia, Piazzale Menghini, 06132 Perugia, Italy, mpirro{at}unipg.it

Francesco Bagaglia

Medicina Interna, Angiologia e Malattie da Arteriosclerosi, Università degli Studi di Perugia, Ospedale S. Maria della Misericordia, Piazzale Menghini, 06132 Perugia, Italy

Lucio Paoletti

Medicina Interna, Angiologia e Malattie da Arteriosclerosi, Università degli Studi di Perugia, Ospedale S. Maria della Misericordia, Piazzale Menghini, 06132 Perugia, Italy

Rolando Razzi

Medicina Interna, Angiologia e Malattie da Arteriosclerosi, Università degli Studi di Perugia, Ospedale S. Maria della Misericordia, Piazzale Menghini, 06132 Perugia, Italy

Massimo R. Mannarino

Medicina Interna, Angiologia e Malattie da Arteriosclerosi, Università degli Studi di Perugia, Ospedale S. Maria della Misericordia, Piazzale Menghini, 06132 Perugia, Italy

Hypercholesterolemia has been associated with increased cardiovascular risk by contributing to mechanical endothelial injury and dysfunction. There is evidence that chronic exposure to increased plasma cholesterol levels might also impair the repair of lipoprotein-mediated endothelial injury, possibly by reducing the availability and function of circulating endothelial progenitors. This review summarizes current knowledge about the mechanisms of lipoprotein-mediated endothelial injury and endothelial progenitor cell assisted vascular repair; the influence of hypercholesterolemia on endothelial progenitor cell dysfunction will be also addressed.

Key Words: endothelial progenitor cells • cholesterol • endothelial dysfunction

This version was published on October 1, 2008

Therapeutic Advances in Cardiovascular Disease, Vol. 2, No. 5, 329-339 (2008)
DOI: 10.1177/1753944708094769
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