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Thiazolidinedione associated volume overload and pulmonary hypertension

Michaelson 5667 Peachtree Dunwoody Rd Suite 350 Atlanta, GA, USA 30342, michaelson{at}bellsouth.net

Thiazolidinediones are currently indicated for the treatment of Type 2 Diabetes. This class of drugs has been associated with several adverse reactions associated with volume overload. This report describes a case of a 65 year old African—American female with a history of hypertension and obesity, and taking rosiglitazone (Avandia) for her Type 2 Diabetes whose evaluation for chest pain resulted in the incidental finding of pulmonary hypertension noted on echocardiogram. The subsequent evaluation, follow-up and treatment are discussed along with potential pitfalls and implications for clinical care.

Key Words: pulmonary hypertension • drugs • echocardiography • heart failure • diabetes mellitus

This version was published on December 1, 2008

Therapeutic Advances in Cardiovascular Disease, Vol. 2, No. 6, 435-438 (2008)
DOI: 10.1177/1753944708093413


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