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Ethanol for cardiac ischemia: the role of protein kinase c

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA

Marie-Helene Disatnik

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA

Grant R. Budas

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA

Daria Mochly-Rosen

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA, mochly{at}stanford.edu

The physiological effects of ethanol are dependent upon the amount and duration of consumption. Chronic excessive consumption can lead to diseases such as liver cirrhosis, and cardiac arrhythmias, while chronic moderate consumption can have therapeutic effects on the cardiovascular system. Recently, it has also been observed that acute administration of ethanol to animals prior to an ischemic event provides significant protection to the heart. This review focuses on the different modalities of chronic vs. acute ethanol consumption and discusses recent evidence for a protective effect of acute ethanol exposure and the possible use of ethanol as a therapeutic agent.

Key Words: PKC • ethanol • ischemic preconditioning • ischemia • reperfusion • cardiac protection

Therapeutic Advances in Cardiovascular Disease, Vol. 2, No. 6, 469-483 (2008)
DOI: 10.1177/1753944708094735


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