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Therapeutic Advances in Cardiovascular Disease
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Effects of alcohol on atrial fibrillation: myths and truths

Carlos E.B. Balbão

Paulista School of Medicine, Federal University of São Paulo, São Paulo, Brazil

Angelo A.V. de Paola

Paulista School of Medicine, Federal University of São Paulo, São Paulo, Brazil

Guilherme Fenelon

Paulista School of Medicine, Federal University of São Paulo, São Paulo, Brazil, guilhermefenelon{at}uol.com.br

Alcohol is the most consumed drug worldwide. Both acute and chronic alcohol use have been associated with cardiac arrhythmias, in particular atrial fibrillation, or so-called 'holiday heart syndrome'. Epidemiological, clinical and experimental studies have attempted to elucidate the mechanisms involved in this association. However, because most of these studies have shown conflicting results, the connection between ethanol and atrial arrhythmias remains controversial. Historical, epidemiological and pharmacological aspects of alcohol, as well as recent concepts on atrial fibrillation are reviewed. We then examine the literature and provide a critical point of view on the still elusive association between alcohol and atrial fibrillation.

Key Words: alcohol use • arrhythmias • atrial fibrillation • electrophysiology

This version was published on February 1, 2009

Therapeutic Advances in Cardiovascular Disease, Vol. 3, No. 1, 53-63 (2009)
DOI: 10.1177/1753944708096380
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