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Therapeutic Advances in Cardiovascular Disease
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A heart full of stem cells: the spectrum of myocardial progenitor cells in the postnatal heart

Christof Stamm

BCRT Berlin-Brandenburg Center for Regenerative Therapies, Berlin, Germany; and Deutsches Herzzentrum Berlin, Cardiothoracic Surgery, Berlin, Germany, stamm{at}dhzb.de

Yeong-Hoon Choi

Deutsches Herzzentrum Berlin, Cardiothoracic Surgery, Berlin, Germany

Boris Nasseri

Deutsches Herzzentrum Berlin, Cardiothoracic Surgery, Berlin, Germany

Roland Hetzer

BCRT Berlin-Brandenburg Center for Regenerative Therapies, Berlin, Germany; and Deutsches Herzzentrum Berlin, Cardiothoracic Surgery, Berlin, Germany

Influencing cellular regeneration processes in the heart has been a long-standing goal in cardiovascular medicine. To some extent, this has been successful in terms of vascular regeneration as well as intercellular connective tissue remodeling processes. Several components of today's routine heart failure medication influence endothelial progenitor cell behavior and support collateral vessel growth in the heart, or have been shown to prevent or reverse fibrosis processes. Cardiomyocyte regeneration, however, has so far escaped therapeutic manipulation strategies. Delivery of exogenous cells of bone marrow origin to the human myocardium may improve heart function, but is not associated with relevant neomyogenesis. However, accumulating evidence indicates that the myocardium contains resident cardiac progenitor cells (CPC) that may be therapeutically useful. This notion indeed represents a paradigm shift but is still controversial. The purpose of this review is to summarize the rapidly expanding current knowledge on CPC, and to assess whether it may be translated into solid therapeutic concepts.

Key Words: Heart disease • stem cell • progenitor cell • regeneration

This version was published on June 1, 2009

Therapeutic Advances in Cardiovascular Disease, Vol. 3, No. 3, 215-229 (2009)
DOI: 10.1177/1753944709336190
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