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Thiazolidinedione associated volume overload and pulmonary hypertension

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	Abstract

Thiazolidinediones are currently indicated for the treatment of Type 2 Diabetes. This class of drugs has been associated with several adverse reactions associated with volume overload. This report describes a case of a 65 year old African–American female with a history of hypertension and obesity, and taking rosiglitazone (Avandia) for her Type 2 Diabetes whose evaluation for chest pain resulted in the incidental finding of pulmonary hypertension noted on echocardiogram. The subsequent evaluation, follow-up and treatment are discussed along with potential pitfalls and implications for clinical care.

Key Words: pulmonary hypertension, drugs, echocardiography, heart failure, diabetes mellitus

First published on August 21, 2008, doi:10.1177/1753944708093413

Therapeutic Advances in Cardiovascular Disease 2008;2:435.

A more recent version of this article appeared on December 1, 2008


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