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Therapeutic Advances in Cardiovascular Disease
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*Cholesterol
*Stem Cells
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Article

Hypercholesterolemia-associated endothelial progenitor cell dysfunction

Matteo Pirro*, Francesco Bagaglia, Lucio Paoletti, Rolando Razzi, and Massimo R. Mannarino

Medicina Interna, Angiologia e Malattie da Arteriosclerosi, Università degli Studi di Perugia, Ospedale S. Maria della Misericordia, Piazzale Menghini, 06132 Perugia, Italy

* To whom correspondence should be addressed.


  Abstract

Hypercholesterolemia has been associated with increased cardiovascular risk by contributing to mechanical endothelial injury and dysfunction. There is evidence that chronic exposure to increased plasma cholesterol levels might also impair the repair of lipoprotein-mediated endothelial injury, possibly by reducing the availability and function of circulating endothelial progenitors. This review summarizes current knowledge about the mechanisms of lipoprotein-mediated endothelial injury and endothelial progenitor cell assisted vascular repair; the influence of hypercholesterolemia on endothelial progenitor cell dysfunction will be also addressed.

Key Words: endothelial progenitor cells, cholesterol, endothelial dysfunction

First published on August 21, 2008, doi:10.1177/1753944708094769

Therapeutic Advances in Cardiovascular Disease 2008;2:329.

A more recent version of this article appeared on October 1, 2008

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